Model Organisms
This webpage was produced as an assignment for Genetics 564, an undergraduate capstone course at UW-Madison.
Model organisms are used in scientific research to study proteins, genes, diseases, etc. when modeling them through humans is not feasible or ethical. Below is a diagram for the phenotypes for common RASopothies (including NF1) exhibited by drosophila (fruit flies), zebrafish, and mice. Focus on the phenotypes listed that have a (1) as their asterisk, these are for NF1.
Model Organism's Databases for NF1
Rattus Norvegicus (Brown Rat)
Mus musculus (House Mouse)
Zebrafish
Drosophila Melanogaster (Fruit Fly)
Mus musculus (House Mouse)
Zebrafish
Drosophila Melanogaster (Fruit Fly)
References
Figure 1: RASopathies: unraveling mechanisms with animal models
Granton A. Jindal, Yogesh Goyal, Rebecca D. Burdine, Katherine A. Rauen, Stanislav Y. Shvartsman
Disease Models & Mechanisms 2015 8: 769-782; doi: 10.1242/dmm.020339
Granton A. Jindal, Yogesh Goyal, Rebecca D. Burdine, Katherine A. Rauen, Stanislav Y. Shvartsman
Disease Models & Mechanisms 2015 8: 769-782; doi: 10.1242/dmm.020339