Gene Ontology
This webpage was produced as an assignment for Genetics 564, an undergraduate capstone course at UW-Madison.
What are Gene Ontologies?
Cellular Component: Terms to describe a component of a cell that is a part of a larger object, such as an anatomical structure of the cell (a nucleus, or a rough endoplasmic reticulum) or a gene product group (such as a ribosome, proteasome, or a protein dimer). [1]
Biological Process: A term that describes a series of events accomplished by one or more organized assemblies of molecular functions. This is not necessarily a biological pathway, but more along the lines of signal transduction, or pyrimidine metabolic processes. [1]
Molecular Function: Terms to describe activities that occur at the molecular level, such as catalytic activity or binding activity. Keep in mind that some of these activities need more than one gene product to be carried out. [1]
Cellular Component: Terms to describe a component of a cell that is a part of a larger object, such as an anatomical structure of the cell (a nucleus, or a rough endoplasmic reticulum) or a gene product group (such as a ribosome, proteasome, or a protein dimer). [1]
Biological Process: A term that describes a series of events accomplished by one or more organized assemblies of molecular functions. This is not necessarily a biological pathway, but more along the lines of signal transduction, or pyrimidine metabolic processes. [1]
Molecular Function: Terms to describe activities that occur at the molecular level, such as catalytic activity or binding activity. Keep in mind that some of these activities need more than one gene product to be carried out. [1]
Gene Ontology for NF1
Cellular Component
- Axon
- Cytoplasm
- Dendrite
- Membrane
- Nucleus
- Presynapse [2]
Molecular Function
- GTPase activator
- Phosphatidylcholine binding
- Phosphatidylethanolamine binding [2]
Biological Process
- Actin cytoskeleton organization
- Cell Comminication
- Cerebral cortex development
- Cognition
- Forebrain astrocyte development
- Forebrain morphogenesis
- gamma-aminobutyric acid secretion, neurotransmission
- Heart development
- Liver Development
- MAPK cascade
- Myelination in peripheral nervous system
- Negative regulation of: angiogenesis, astrocyte differentiation, cell-matrix adhesion, cell migration, endothelial cell proliferation, fibroblast proliferation, MAPK cascade, neuroblast proliferation, neurotransmitter secretion, oligodendrocyte differentiation, Ras protein signal transduction
- Neural tube development
- Observational learning
- Positive regulation of: adenylate cyclase activity, apoptotic process, GTPase activity, neuron apoptotic process
References
[1] Ontology Documentation. Gene Ontology Consortium. http://geneontology.org/page/ontology-documentation
[2] UniProt NF1. http://www.uniprot.org/uniprot/P21359
Figure 1: Leiff, Jon. Non Immune Cells Also Combat Microbes. http://jonlieffmd.com/tag/cell-compartments-used-to-sequester-and-kill-microbes
[2] UniProt NF1. http://www.uniprot.org/uniprot/P21359
Figure 1: Leiff, Jon. Non Immune Cells Also Combat Microbes. http://jonlieffmd.com/tag/cell-compartments-used-to-sequester-and-kill-microbes